金天格胶囊对骨质疏松骨折患者炎性反应递质表达的影响(1)
摘要 目的：探讨金天格胶囊对骨质疏松骨折患者炎性反应递质表达的影响。方法：选取2016年1月至2016年12月昆明市延安医院收治的骨质疏松性骨折140例作为研究对象，按照入组先后顺序分为观察组与对照组，每组70例，对照组给予口服钙尔奇D3元素片，观察组给予金天格胶囊口服，疗程6个月。结果：治疗3个月后肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)-1、IL-6、IL-10、IL-17及单核细胞趋化蛋白-1(MCP-1)水平观察组显著低于对照组，差异有统计学意义( P <0.05);观察组治疗6个月后TNF-α、IL-1、IL-10、IL-17及MCP-1水平显著低于对照组，差异有统计学意义( P <0.05);观察组治疗6个月后的L1-4骨密度高于对照组，差异有统计学意义( P <0.05);骨质疏松后骨折患者L1-4骨密度平与TNF-α、IL-1、IL-10、IL-17及MCP-1呈负相关( P <0.05)。结论：金天格胶囊可有效提升骨质疏松骨折患者L1-4骨密度，抑制骨细胞炎性反应递质表达可能是骨密度提升的机制之一。
关键词 金天格胶囊;骨质疏松;骨折;炎性反应递质;骨密度;单核细胞趋化蛋白-1;肿瘤坏死因子-α;白细胞介素
Effects of Jintiange Capsules on Expression of Inflammatory Factors in Patients with Osteoporotic Fracture
Zhu Yuanwang，Mao Xihong
(Yan′an Hospital of Kunming City，Kunming 650500，China)
Abstract Objective： To explore the effects of Jintiange Capsules on the expression of inflammatory factors in patients with osteoporotic fracture. Methods： A total of 140 cases of patients with osteoporotic fracture admitted to Yan′an Hospital of Kunming City from January 2016 to December 2016 were included and were divided into study group and control group according to the joining order，with 70 cases in each group.The control group was given oral calcium element tablets of Caltrate，while the study group was given Jintiange Capsules orally for 6 months. Results： The levels of TNF-α，IL-1，IL-6，IL-10，IL-17 and MCP-1 of the study group were significantly lower than those of the control group after 3 months of treatment.The levels of TNF-Α，IL-1，IL-10，IL-17 and MCP-1 of the study group were significantly lower than those of the control group after 6 months of treatment ( P <0.05).The levels of L1-4 BMD of the study group was significantly higher than that of the control group at the same period ( P <0.05).The level of L1-4 BMD in patients with osteoporosis showed a significant negative correlation with TNF-α，IL-1，IL-10，IL-17 and MCP-1 ( P <0.05). Conclusion： Jintiange Capsules can effectively improve the bone mineral density of L1-4 bone in patients with osteoporotic fracture，and one of the mechanisms may be its effects in suppressing the expression of inflammatory factors of bone cells.
Key Words Jintiange Capsule; Osteoporosis; Fracture; Inflammatory factor; Bone density; Monocyte chemoattractant protein-1; Tumor necrosis factor-α; Interleukin
中圖分类号：R289.5;R681.7 文献标识码：A doi： 10.3969/j.issn.1673-7202.2019.02.040
骨质疏松是以骨量减少、骨密度损失、骨围观结构退化、骨组织丧失正常结构及连接为特点，引发骨脆性增加、强度下降，易出现脆性骨折的代谢性疾病，骨质疏松脆性骨折后，再骨折率及死亡风险将显著上升。流行病学报道显示，老年骨质疏松性骨折占骨折比例8.06%，占住院人数的5.86%，且呈现逐年上升趋势[1]。金天格胶囊为我国自主研发的中药一类新药，经应用仿生学研究，采用非保护动物特定部位骨骼，以天然虎骨为特征图标研制的新一代虎骨替代用品制剂，中医学认为虎骨可祛风镇痛、强筋健骨、缓解腰背疼痛等。近年来金天格胶囊被广泛的应用于骨质疏松治疗、促进骨质疏松骨折愈合治疗、强直性脊柱炎、膝骨关节炎的治疗，疗效理想[2-3]。慢性炎性反应过程被认为是骨质疏松的重要病理生理过程，本研究分析金天格胶囊对骨折疏松患者血清炎性反应递质水平表达的影响。现报道如下。, 百拇医药(朱远旺 毛希宏)
关键词 金天格胶囊;骨质疏松;骨折;炎性反应递质;骨密度;单核细胞趋化蛋白-1;肿瘤坏死因子-α;白细胞介素
Effects of Jintiange Capsules on Expression of Inflammatory Factors in Patients with Osteoporotic Fracture
Zhu Yuanwang，Mao Xihong
(Yan′an Hospital of Kunming City，Kunming 650500，China)
Abstract Objective： To explore the effects of Jintiange Capsules on the expression of inflammatory factors in patients with osteoporotic fracture. Methods： A total of 140 cases of patients with osteoporotic fracture admitted to Yan′an Hospital of Kunming City from January 2016 to December 2016 were included and were divided into study group and control group according to the joining order，with 70 cases in each group.The control group was given oral calcium element tablets of Caltrate，while the study group was given Jintiange Capsules orally for 6 months. Results： The levels of TNF-α，IL-1，IL-6，IL-10，IL-17 and MCP-1 of the study group were significantly lower than those of the control group after 3 months of treatment.The levels of TNF-Α，IL-1，IL-10，IL-17 and MCP-1 of the study group were significantly lower than those of the control group after 6 months of treatment ( P <0.05).The levels of L1-4 BMD of the study group was significantly higher than that of the control group at the same period ( P <0.05).The level of L1-4 BMD in patients with osteoporosis showed a significant negative correlation with TNF-α，IL-1，IL-10，IL-17 and MCP-1 ( P <0.05). Conclusion： Jintiange Capsules can effectively improve the bone mineral density of L1-4 bone in patients with osteoporotic fracture，and one of the mechanisms may be its effects in suppressing the expression of inflammatory factors of bone cells.
Key Words Jintiange Capsule; Osteoporosis; Fracture; Inflammatory factor; Bone density; Monocyte chemoattractant protein-1; Tumor necrosis factor-α; Interleukin
中圖分类号：R289.5;R681.7 文献标识码：A doi： 10.3969/j.issn.1673-7202.2019.02.040
骨质疏松是以骨量减少、骨密度损失、骨围观结构退化、骨组织丧失正常结构及连接为特点，引发骨脆性增加、强度下降，易出现脆性骨折的代谢性疾病，骨质疏松脆性骨折后，再骨折率及死亡风险将显著上升。流行病学报道显示，老年骨质疏松性骨折占骨折比例8.06%，占住院人数的5.86%，且呈现逐年上升趋势[1]。金天格胶囊为我国自主研发的中药一类新药，经应用仿生学研究，采用非保护动物特定部位骨骼，以天然虎骨为特征图标研制的新一代虎骨替代用品制剂，中医学认为虎骨可祛风镇痛、强筋健骨、缓解腰背疼痛等。近年来金天格胶囊被广泛的应用于骨质疏松治疗、促进骨质疏松骨折愈合治疗、强直性脊柱炎、膝骨关节炎的治疗，疗效理想[2-3]。慢性炎性反应过程被认为是骨质疏松的重要病理生理过程，本研究分析金天格胶囊对骨折疏松患者血清炎性反应递质水平表达的影响。现报道如下。, 百拇医药(朱远旺 毛希宏)
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